New Study Shows that CBD Reduces Tumors in Dogs
The CBD nanoemulsion reduced malignant tumor cells in dogs
Researchers at the University of Chile have developed a CBD nanoemulsion that successfully reduced malignant tumor cells in an in vitro model. The next step is to test this formulation on animal models, specifically focusing on breast cancer in dogs.
Veterinary researcher Francisca Medina has successfully delivered CBD in a sustained manner within an in vitro model, effectively halting the growth and reproduction of cancer cells. This research, part of the PhD program in Forestry, Agriculture, and Veterinary Sciences at the University of Chile, has shown that CBD nanoemulsions can slow the progression of breast cancer by inhibiting both the proliferation and migration of tumor cells in dogs.
How was the CBD Administered in the Study?
One significant challenge in applying CBD therapeutically is its low water solubility, which limits absorption and dosage. To address this issue, researchers created a CBD nanoemulsion (CBD-Nem), an oil-in-water formulation that encapsulates the cannabinoid in tiny lipid particles, thereby enhancing its bioavailability within the endocannabinoid system.
How Could this Help With Human Medical Research?
Medina's in vitro model was able to release CBD effectively for 20 days without losing potency, marking a notable achievement in biological sciences and published in the journal *Pharmaceutics*. The team plans to advance their studies to animal models to further assess potential efficacy. "We want to progress with studies in mice and later in dogs, evaluating not just the antitumor effects but also the systemic safety," Medina explained. “CBD has shown efficacy against various tumors, and the nanoemulsion enhances its action. We do not rule out the possibility that this research could also apply to melanoma or other epithelial tissue cancers in both dogs and humans.”
Medina highlighted the potential implications for human medicine, having developed an original method for encapsulating CBD. “Laboratory tests demonstrated that the nanoemulsion not only reduced the viability of neoplastic cells but also inhibited their ability to migrate and invade other tissues—a crucial factor in the process of metastasis. Furthermore, it significantly reduced the formation of tumor colonies for 20 days, showcasing a prolonged effect,” the university's website noted.
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